Mohsen M.T. Al-Saleh; Dr. Saif Al-Yahharubi; Dr. Khamis Al-Hashmi; Dr. Ibrahim Al-Zakwani Professor; Ms. Saud Al-Makhainya; Dr. Humood Al-Dhuhli Riad Bayoumi; Dr. Khalid Al-Rasadi Department of Biochemistry; College of Medicine and Health Sciences (COMHS), Sultan Qaboos University (SQU), Al-Khoudh, Muscat.
Abstract: Chronic vitamin D deficiency in children causes bone deformities from poor mineralization. Type 1 diabetes mellitus (T1DM) also negatively affect bone density and strength. Recent evidence suggests a role of vitamin D in the pathogenesis and prevention of T1DM. Vitamin D receptors are present in pancreatic ß-cells and vitamin D is essential for normal insulin secretion. Islet cell insulin secretion is reduced in vitamin D-deficient animals and can be corrected by vitamin D supplementation. Type 1 DM is an autoimmune disease, and the self immune system plays a central role in the destruction of the ß-cell. Vitamin D plays a potential role as an immunomodulator. Chronic administration of pharmacological doses of vitamin D reduces the incidence of both insulitis and diabetes in NOD. Several studies from Italy, Sweden, and Australia, found low levels of vitamin D in T1DM compared to controls. A study at the University of Arkansas showed that T1DM might cause vitamin D deficiency because of an increase in the urinary excretion of vitamin D binding protein (VDBP). The diabetic subjects had lower levels of vitamin D in the blood, along with higher levels of both vitamin D binding protein and albumin in the urine. Aims of this study were to estimate the prevalence of vitamin D deficiency in T1DM and to correlate between vitamin D levels and HbA1c as marker for glycemic controls in T1DM. In addition; measuring the urinary concentration of both U-albumin and VDBP in T1DM and controls. Beside that to do correlation between inflammatory marker, vitamin D and HbA1c in T1DM patients and aged matched normal control Omani children.