Serum Oxidized Low Density Lipoprotein (oxLDL) levels are increased in hyperlipidemic subjects but not associated with LDL size

Hamed Al-Riyami, Mohsin Al-Saleh and Jumana Saleh Biochemistry department, Faculty of Medicine, Sultan Qaboos University, Muscat, Oman It is well established that hyperlipidemia is associated with formation of smaller, denser LDL particles (sdLDL) in plasma. Many studies suggested that sdLDL particles have increased atherogenicity compared to larger buoyant subtypes. Several reasons were suggested in this[…]



Association of Plasma Oxidized Low Density Lipoprotein (oxLDL) with increased triglycerides level in Omani subjects

Oxidation of low density lipoproteins (LDL) is a modification believed to be a key event in the development of atherosclerosis. Oxidized LDL (oxLDL) particles are recognized by macrophage scavenger receptors where macrophages become loaded with cholesterol converting into “foam cells” that accumulate into fatty streaks initiating atherosclerosis events. In vitro studies suggest that small LDL[…]



Fundamentals of HPLC courses by GSC

Please click on below links to download the course file: 1-What is HPLC? 2-Basic terms and concepts. 3-HPLC instrumentation and trends. 4-Introduction to chromatography software. 5-Types of HPLC; isocratic & gradient. 6-Qualitative and quantitative determination.  7-Normal & reverse phase chromatography modes. 8-HPLC column and trends. 9-Column selection in reverse phase chromatography. 10-HPLC method development. 11-Regulatory[…]



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The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels

Immunoprecipitation assay It is the technique of precipitating a protein “antigen” out of solution using “an antibody” that specifically binds to that particular protein “antigen” in a complex This process can be used to isolate and concentrate a particular protein from a sample containing many thousands of different proteins Immunoprecipitation requires that the antibody be[…]